Iron stores related to iron absorption

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Effect of iron stores and hysterectomy on iron absorption and distribution in pregnant mice.

Intestinal uptake (U) and transport (T) of 50Fe from a 1-mug oral dose was studied in the mouse. U increased to a similar degree in both pregnant and iron-deficient animals. The increase in T was greater in pregnant than in iron-deficient mice. In iron-loaded pregnant mice, U increased to levels found in pregnant animals, whereas T increased, but by a lesser amount. Termination of pregnancy by ...

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The Role of Hepatic Iron Stores in the Control of Iron Absorption.

The mechanisms that regulate iron absorption l)y the gastrointestinal tract are not known. Clinical and experimental work suggests that decreased iron stores (1-3) or increased rate of erythropoiesis (2, 4) may be factors causing increased absorption of iron from the gut. The purpose of this paper is to describe the role of the hepatic iron stores as a stimulus to intestinal absorption of iron....

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Iron stores in pregnancy.

Serum ferritin concentration has been measured during the course of pregnancy in 154 women. There was a rapid decrease in iron stores during early pregnancy irrespective of any iron therapy. Oral iron did, however, prevent the stores reaching iron deficient levels during the second half of pregnancy. The results suggest that maternal erythroid activity starts early in pregnancy and may exhaust ...

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Metabolism of Iron Stores

Remarkable progress was recently achieved in the studies on molecular regulators of iron metabolism. Among the main regulators, storage iron, iron absorption, erythropoiesis and hepcidin interact in keeping iron homeostasis. Diseases with gene-mutations resulting in iron overload, iron deficiency, and local iron deposition have been introduced in relation to the regulators of storage iron metab...

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Adaptation in iron absorption: iron supplementation reduces nonheme-iron but not heme-iron absorption from food.

BACKGROUND Results of cross-sectional studies suggest that in healthy people, iron absorption adapts to meet physiologic needs and stabilize iron stores, but this has not been adequately tested in longitudinal studies. OBJECTIVE We tested whether heme- and nonheme-iron absorption decrease in response to increased iron intake and whether iron stores reach a steady state. DESIGN In a randomiz...

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ژورنال

عنوان ژورنال: The American Journal of Clinical Nutrition

سال: 1997

ISSN: 0002-9165,1938-3207

DOI: 10.1093/ajcn/66.6.1483a